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Published on: 2011-12-26
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Original language: English

Systemic lupus erythematosus (SLE) is an autoimmune disease affecting multiple organ systems. Neuropsychiatric (NP) manifestations are a major cause of morbidity and mortality in patients with SLE. The prevalence of NPSLE ranges widely reflecting variable diagnostic criteria and differences in selection of patients for study. The pathogenesis of NPSLE is still unclear. This study was done to describe the prevalence of NP syndromes in a Finnish population of patients with SLE and classify them according to the American College of Rheumatology (ACR) nomenclature and case definitions for NPSLE; to assess the validity of the ACR nomenclature system; to evaluate whether serum matrix metalloproteinase-9 (MMP-9) levels are associated with NP manifestations and to evaluate the volumetric brain magnetic resonance imaging (MRI) findings in SLE patients.The study group consisted of 46 SLE patients and an equal amount of matched controls. A complete medical history was obtained from all and a clinical neurological examination was performed by the same neurologist. All past and present NP syndromes were listed and classified according to the ACR nomenclature and case definitions. Individual disease activity and an accumulated NP abnormality were assessed by using standardized scores. A cumulative lifetime dose of glucucorticoids was derived from the medical records. Laboratory tests including anticardiolipin antibodies and a quantification of immunoreactive MMP-9 were done for all. A battery of standardized neuropsychological tests and a clinical interview by the psychologist were performed in order to detect a possible cognitive deficit, depression or anxiety disorder. Cerebral MRI was done for all study subjects. Volumetric measures of cerebral atrophy as well as T1- and T2-weighted lesions were obtained.At least one NP syndrome was identified in 91% of SLE patients in this population-based study. Cognitive dysfunction was the most frequent single manifestation followed by headache and mood disorder. When mild NP syndromes (mild cognitive deficit, headache, mild depression, anxiety and polyneuropathy with normal ENMG findings) were excluded, the prevalence of NPSLE dropped to 46%.All NPSLE syndromes were more frequent among SLE patients than controls. However, most syndromes were also found among controls, which resulted in low specificity. To improve the criteria we constructed revised criteria based on objective findings only. We entirely excluded mild NP syndromes and with this modification, the proportion of controls fulfilling at least 1 of the criteria was substantially lower (7% versus 54%). NIH Guide: NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS NEUROPSYCHIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS ... Systemic lupus erythematosus ... Vascular events also appear to contribute to CNS involvement in lupus. Neuropsychiatric involvement in pediatric systemic lupus ... Neuropsychiatric involvement in pediatric systemic lupus erythematosus. ... Neuropsychiatric ... Lupus Erythematosus Systemic/diagnosis* [PDF] Neuropsychiatric Involvement in Systemic Lupus ... Read or Download Here read.ebookbook.net/?book=9514486137[PDF] Neuropsychiatric Involvement in Systemic Lupus Erythematosus (Acta Universitatis ... Neuropsychiatric Involvement in Systemic Lupus Erythematosus Neuropsychiatric Involvement in Systemic Lupus Erythematosus ... Acta Universitatis Tamperensis 1672 ... NPSLE Neuropsychiatric systemic lupus erythematosus Neuropsychiatric involvement in juvenile systemic lupus ... S. Neuropsychiatric involvement in juvenile ... systemic lupus erythematosus neuropsychiatric ... Neuropsychiatric involvement in systemic lupus erythematosus ... Neuropsychiatric Systemic Lupus Erythematosus Neuropsychiatric systemic lupus erythematosus (NPSLE) ... Neurological involvement in SLE commonly called neuropsychiatric lupus (NPSLE) is the Neuropsychiatric Involvement in Systemic Lupus Erythematosus Neuropsychiatric Involvement in Systemic Lupus Erythematosus Neuropsychiatric Involvement in Systemic Lupus ... Neuropsychiatric Involvement in Systemic Lupus Erythematosus (Acta Universitatis Tamperensis): ... Acta Universitatis Tamperensis; Increased serum matrix metalloproteinase 9 levels in ... ... lupus erythematosus patients with neuropsychiatric ... reflect neuropsychiatric involvement ... with neuropsychiatric systemic lupus erythematosus ... Managing Neuropsychiatric Lupus: Top 10 Clinical Pearls ... Managing Neuropsychiatric Lupus: ... woman with neuropsychiatric systemic lupus erythematosus ... system involvement in systemic lupus erythematosus: ...
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